I did not have the space to write my comment, so I am adding this as answer to contribute to the debate.
It is important to distinguish the concepts of realizability in terms of "admitting a state-space realization" and "admitting a physical realization." The OP asked about former, and the answer by Rodrigo de Azevedo is correct (it is only proving one side of the implication; the general proof can be found in, e.g., Theorem 3.3, Chapter 5, of Linear Systems by Antsaklis and Michel). Sure, you can hack your state-space formulation by adding input derivatives, but then it is not a state-space realization, it is another type of system description.
The answer by Pait is more on "admitting a physical realization". It is not correct, because there are several devices compute derivatives. E.g., Ogata's Modern Control Engineering, Chap. 3, shows several circuits using resistors, capacitors, and operational amplifiers to build PD or PID controllers, which have improper transfer functions. A pure differentiator can be build with a capacitor, a resistor, and an OpAmp, see here.
Now, notice that every improper transfer function will be the sum of a few derivatives and a proper transfer function (just do polynomial division). The general issue with why, in practice, time-derivatives are avoided, is because they amplify noise. Noise is often modeled as a stochastic (aka random) process, the purest of it being the so-called white noise. One of the main "features" of the white noise is that its power spectral density is constant, meaning that all frequencies are present. Differentiating white noise gives infinite gain at infinite frequency, meaning that, in practice, you immediately obtain immense noise. Integrating white noise generates the Wiener process (or the Brown noise, depending on the formalism you pick), which generally drifts towards infinity as time goes to infinity... so there is a long-term problem with integration as well. Hence, Pait is right in the sense that differentiating creates an instantaneous problem, while integrating does not.