First identity:
$$
\boxed{\sum_{k} \left(-4\right)^{-k} {2k \choose k} {l \choose k} {k \choose a} = \frac{(-1)^a}{4^l} {2a \choose a} {2l - 2a \choose l-a}}
$$
Note that
$$
\binom{l}{k} \binom{k}{a} = \binom{l}{a} \binom{l-a}{l-k},
$$
so we can factor out $\binom{l}{a}$:
$$
\binom{l}{a} \sum\limits_k (-4)^{-k} \binom{2k}{k} \binom{l-a}{l-k}
$$
Now, we substitute $\binom{l-a}{l-k} = [x^l] x^k (1+x)^{l-a}$:
$$
\binom{l}{a} [x^l] (1+x)^{l-a} \sum\limits_k \binom{2k}{k} (-4)^{-k}x^k
$$
Using the standard expansion $\frac{1}{\sqrt{1-4x}} = \sum\limits_k \binom{2k}{k} x^k$, we collapse the sum into
$$
\binom{l}{a} [x^l] \frac{(1+x)^{l-a}}{\sqrt{1+x}} = \binom{l}{a} \binom{l-a-\frac{1}{2}}{l},
$$
which can be proven to be the same as RHS via Gamma function, or some "menial labor".
Second identity:
$$
\boxed{\sum_{k} (-4)^{-k} {2k-2a \choose k-a} {l \choose k} = \frac{(-1)^a}{4^l} \frac{{2l \choose l}{l \choose a}}{{2a \choose a}}}
$$
We can substitute $\binom{2k-2a}{k-a} =[x^{l-a}] x^{l-k} \frac{1}{\sqrt{1-4x}}$, which turns the sum into
$$
[x^{l-a}]\frac{1}{\sqrt{1-4x}}\sum\limits_k \binom{l}{k} (-4)^{-k} x^{l-k},
$$
which, by binomial theorem, is equal to
$$
[x^{l-a}] \frac{1}{\sqrt{1-4x}}\left(x-\frac{1}{4}\right)^l = (-4)^{-l}[x^{l-a}]\frac{(1-4x)^l}{\sqrt{1-4x}}=(-4)^{-a}\binom{l-\frac{1}{2}}{l-a},
$$
and some further manual verification again confirms that it is equal to the RHS.