$\newcommand{\+}{^{\dagger}}
\newcommand{\angles}[1]{\left\langle #1 \right\rangle}
\newcommand{\braces}[1]{\left\lbrace #1 \right\rbrace}
\newcommand{\bracks}[1]{\left\lbrack #1 \right\rbrack}
\newcommand{\ceil}[1]{\,\left\lceil #1 \right\rceil\,}
\newcommand{\dd}{{\rm d}}
\newcommand{\down}{\downarrow}
\newcommand{\ds}[1]{\displaystyle{#1}}
\newcommand{\equalby}[1]{{#1 \atop {= \atop \vphantom{\huge A}}}}
\newcommand{\expo}[1]{\,{\rm e}^{#1}\,}
\newcommand{\fermi}{\,{\rm f}}
\newcommand{\floor}[1]{\,\left\lfloor #1 \right\rfloor\,}
\newcommand{\half}{{1 \over 2}}
\newcommand{\ic}{{\rm i}}
\newcommand{\iff}{\Longleftrightarrow}
\newcommand{\imp}{\Longrightarrow}
\newcommand{\isdiv}{\,\left.\right\vert\,}
\newcommand{\ket}[1]{\left\vert #1\right\rangle}
\newcommand{\ol}[1]{\overline{#1}}
\newcommand{\pars}[1]{\left( #1 \right)}
\newcommand{\partiald}[3][]{\frac{\partial^{#1} #2}{\partial #3^{#1}}}
\newcommand{\pp}{{\cal P}}
\newcommand{\root}[2][]{\,\sqrt[#1]{\vphantom{\large A}\,#2\,}\,}
\newcommand{\sech}{\,{\rm sech}}
\newcommand{\sgn}{\,{\rm sgn}}
\newcommand{\totald}[3][]{\frac{{\rm d}^{#1} #2}{{\rm d} #3^{#1}}}
\newcommand{\ul}[1]{\underline{#1}}
\newcommand{\verts}[1]{\left\vert\, #1 \,\right\vert}$
$\ds{\sum_{i=0}^{1000}\pars{-1}^{i}{1000 \choose i}\pars{100 - i}^{500} = 0:\
{\large ?}}$
\begin{align}
&\sum_{i=0}^{1000}\pars{-1}^{i}{1000 \choose i}\pars{100 - i}^{500}
=\sum_{i=0}^{1000}\pars{-1}^{i}{1000 \choose i}\sum_{\ell = 0}^{500}
{500 \choose \ell}100^{500 - \ell}\pars{-i}^{\ell}
\\[3mm]&=\sum_{\ell = 0}^{500}{500 \choose \ell}\pars{-1}^{\ell}100^{500 - \ell}
\underbrace{\sum_{i=0}^{1000}{1000 \choose i}\pars{-1}^{i}i^{\ell}}
_{\ds{=\ 0;\quad\mbox{See bellow}}}
\end{align}
\begin{align}
\pars{1 - z}^{1000}&=\sum_{i = 0}^{1000}{1000 \choose i}\pars{-1}^{i}z^{i}
\\
-1000z\pars{1 - z}^{999}&=\sum_{i = 0}^{1000}{1000 \choose i}\pars{-1}^{i}iz^{i}
\\
-1000z\pars{1 - z}^{999} + 1000\times999 z^{2}\pars{1 - z}^{998}&
=\sum_{i = 0}^{1000}{1000 \choose i}\pars{-1}^{i}i^{2}z^{i}\,,
\end{align}
If we continue this procedure we get increasing powers of $i$ ( up to $i^{\ell}$ with $\ell \leq 500$ ) in the right member.
Then, set $z = 1$ in both members and we'see that all the sums vanish out.